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Bifunctional SERS Paper Chips Based on Three-Layered Plasmonic Metal-Coated ZnO Nanoflowers for Fast Enrichment and Ultrasensitive Detection of Multiple Antibiotics TEXT SIZE: A A A

In this study, cellulose filter paper (CFP) was used to create three-dimensional ZnO nanoflowers coated with three-layered plasmonic metals (Ag@Au@Ag) by using an in situ generated method. The substrate was created as a surface-enhanced Raman scattering (SERS) paper chip with dual functions for quick enrichment and ultrasensitive antibiotic detection. It was possible to detect amoxicillin, ciprofloxacin, and tetracycline quantitatively with good linear responses at low detection limits of 1, 10, and 10 nM, respectively, thanks to the characteristics of three-dimensional nanostructures, the charge transfer effect of ZnO-plasmonic metal, and electromagnetic coupling of Ag@Au@Ag. Even with a paper chip and a mobile phone-Raman spectrometer integrated system, it was possible to identify human urine antibiotics at ppb levels with high accuracy. Meanwhile, 10 min detection of the antibiotics was accomplished by merely soaking them in their analyte solutions due to CFP wicking. With the help of PCA-LDA analysis, the multiplexed SERS spectral data of the three antibiotics could be successfully separated. Additionally, the paper chip's exceptional mechanical endurance even against 30-fold and strong ultrasonication was made possible by the in situ growing method. The bifunctional, affordable, and long-lasting SERS paper chip has a lot of potential for on-site and point-of-care drug detection.

Publication name

 Acs Applied Nano Materials, DOI 10.1021/acsanm.3c03467, Early Access SEP 2023

Author(s)

 Yan, Juanjuan; Wang, Morui; Yin, Huaiqin; Ma, Mengmeng; Li, Yuee; Hu, Haiyuan; Ye, Weichun; Li, Yumin; Zhang, Hua

Corresponding author(s) 

 Ye, Weichun
 yewch@lzu.edu.cn
 -Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
 -Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China
 Li, Yuee
 liyuee@lzu.edu.cn
 Lanzhou Univ, Sch Informat Sci & Engn, Lanzhou 730000, Peoples R China
 Li, Yumin
 liym@lzu.edu.cn
 Lanzhou Univ, Key Lab Digest Syst Tumors, Lanzhou 730000, Peoples R China
 Zhang, Hua
 zhanghua@mail.gyig.ac.cn
 Chinese Acad Sci, Inst Geochem, State Key Lab Environm Geochem, Guiyang 550081, Peoples R China

Author(s) from IGCAS   Zhang, Hua

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