The sources and temporal evolution of fluids related to distal skarn mineralization strongly influence the minerals that form, but remain poorly understood. In this study, we use the lithium and chlorine isotopic compositions of fluid-inclusion leachates (FIL) to elucidate the nature and evolution of fluids that formed the Luziyuan distal skarn Zn-Pb-Fe-(Cu) deposit, China. The delta Li-7 values of prograde skarn stage rhodonite FIL (+5.37 parts per thousand-+ 7.31 parts per thousand) are similar to those of typical magmatic fluid. The delta Li-7 values (+11.69 parts per thousand-+12.54 parts per thousand) of actinolite FIL are higher than those of rhodonite FIL; this is attributed to Rayleigh fractionation within a closed magmatic-hydrothermal system. It is inferred that up to 70% of fluid-borne Li is sequestered by hydrous minerals during retrograde skarn alteration, consistent with conclusions drawn from previous studies of fluid-inclusions. The delta Li-7 values of galena FIL (+9.78 parts per thousand-+13.19 parts per thousand), black sphalerite FIL (+11.62 parts per thousand), and reddish-brown sphalerite (+10.44 parts per thousand-+11.66 parts per thousand) overlap with those of actinolite FIL, indicating that phase separation occurred during Zn-Pb mineralization at the Luziyuan deposit. The low delta Li-7 values of light-yellow sphalerite FIL (+6.75 parts per thousand) and calcite FIL (+3.95 parts per thousand-+6.49 parts per thousand) record external fluid input, probably meteoric water. The positive delta Cl-37 values of rhodonite FIL (+1.82 parts per thousand-+1.83 parts per thousand) are consistent with those of magmatic fluids. However, the delta Cl-37 values of actinolite FIL (+0.49 parts per thousand) are lower than those of rhodonite FIL, indicating that FIL within hydrous minerals might not record fluid sources reliably.