Ecosystem services (ESs) synergies have been broadly studied, whose synergy control areas and driving mechanisms were still not fully understood. Here, We analyzed soil conservation (SC), water yield (WY), net primary productivity (NPP) and food supply (FS) on the basis of geospatial analysis techniques from 1992 to 2015. The results showed that the SW karst areas contributed 23.7% of SC and 14.56% of NPP with only 8.4% of China's continent. 49.28% of China's land was synergy control areas, while accounted for 82.23% in the SW karst areas. The cause of this phenomenon was twofold, one was the significant increase in NDVI was mainly due to human activities (HA), and the coincidence rates between the HA dominated areas and the synergies control areas up to 90.7%. These results emphasized that ecological engineering was a key factor of the synergy among multi-ESs, the synergy control areas should be priority for ecological restoration.