Climate change will impact every aspect of biophysical systems and society. However, unlike other components of the climate system, the impact of climate change on the groundwater system has only recently received attention. This focus is due to the realization that groundwater is a vital freshwater resource crucial to global food and water security, and is essential in sustaining ecosystems and human adaptation to climate variability and change. This paper synthesizes findings on the direct and indirect impacts of climate change on the entire groundwater system and each component. Also, we appraise the use of coupled groundwater-climate and land surface models in groundwater hydrology as a means of improving existing knowledge of climate change-groundwater interaction, finding that most models anticipate decreases in groundwater recharge, storage and levels, particularly in the arid/semi-arid tropics. Reducing uncertainties in future climate projections and improving our understanding of the physical processes underlying models to improve their simulation of real-world conditions remain a priority for climate and Earth scientists. Despite the enormous progress made, there are still few and inadequate local and regional aquifer studies, especially in less developed regions. The paper proposes two key considerations. First, physical basis: the need for a deeper grasp of complex physical processes and feedback mechanism with the use of more sophisticated models. Second, the need to understand the socioeconomic dimensions of climate-groundwater interaction through multidisciplinary synergy, leading to the development of better groundwater-climate change adaptation strategies and modeling.