Synchronously controlling the nitrogen (N) and phosphorus (P) release from sediments is an important basis for eutrophication management in lakes, but it is still a technical challenge at present. Loading nano-bubbles on the surface of natural minerals to increase dissolved oxygen(DO) level at the sediment- water interface (SWI) provides a possible solution to this problem. In this study, oxygen nano-bubble modified mineral (ONBMM) technology was developed, and its efficiency of oxygenation at the SWI and effect on the removal of internal nutrient input were evaluated under simulated conditions. The results showed that ONBMM effectively improved DO levels near the SWI; the highest concentration reached 6.55 mgL(-1). Meanwhile, adding ONBMM remarkably reduced the concentrations of total P(TP), total N(TN) and ammonia N(NH3-N) in the overlying water. Compared with the control group, the fluxes of TP, NH3-N, and TN loading from sediments in simulation cores treated with ONBMM reduced by 96.4%, 51.1%, and 24.9%, respectively. The high-resolution data obtained by DGT showed that ONBMM effectively inhibited the reduction and release of Fe\\P through increasing the oxygen level at the SWI. The results of 16S rRNA high-throughput sequencing showed that adding ONBMM strengthened the role of nitrobacteria, denitrifying bacteria, and ammonia oxidation bacteria at the SWI. The ONBMM technology provides a new tool to achieve oxygenation at the SWI and in situ control of internal pollution in eutrophic lakes. (C) 2020 Elsevier B.V. All rights reserved.