The Yiliu tungsten polymetallic deposit, located in the south central portion of the Nanling nonferrous metal metallogenic province in South China, is an area with common Yanshanian tectonothermal events. Early Yanshanian magmatism leads to the emplacement of voluminous tungsten-bearing granite intrusions, such as the Baoshan, Benggangling and Junye plutons, which are considered temporally and spatially associated with W-polymetallic mineralization in the Yiliu region. Here, we investigate the basic geological and petrological characteristics of the Junye granites, and present major and trace element geochemical data and bulk-rock Sr-Nd-Pb-Hf isotopic data to gain insight into the petrogenesis and tectonic setting of granitic intrusions in the region. The Junye granites are high-K calc-alkaline and metaluminous to weakly peraluminous [A/CNK = molar ratios of Al2O3/(CaO + Na2O + K2O) = 0.97-1.02] with enrichment in SiO2(75.68-76.44 wt.%), relatively high total alkalis (K2O + Na2O = 8.06-8.45 wt.%) with K2O/Na2O ratios ranging from 1.12 to 1.42, and moderate Al2O3(12.62-13.00 wt.%), but low in P2O5(<0.01 wt.%), MgO (0.02-0.04 wt.%), CaO (0.78-0.95 wt.%) and Fe2O3T(0.93-1.07 wt.%). They show spectacular tetrad effect REE (rare earth element) patterns with low sigma REE content (53.2-145.3 ppm), negative Eu anomalies (delta Eu = 0.09-0.17) and slight enrichment of LREEs (light rare earth elements) relative to HREEs (heavy rare earth elements). The granites are enriched in Rb (481-860 ppm), Th (16.2-46.1 ppm) and U (25.4-40.8 ppm) but depleted in Ba (1.0-5.8 ppm), Sr (11.1-23.4 ppm), P (9.5-26.7 ppm) and Ti (241-393 ppm). All geochemical features lead us to interpret the Junye granites as highly fractionated I-type granites. These granites underwent intense interaction between highly evolved magma and volatile-rich hydrothermal fluids during the late stage of formation, and accompanied fractional crystallization of biotite, plagioclase and accessory minerals, such as apatite, monazite and allanite. Additionally, the granites show uniform Nd isotopic ratios with calculated epsilon Nd (152 Ma) values of -8.28 to -8.91 and Nd model age (T-DM2) of 1645 to 1698 Ma, stable age-corrected initial Pb isotopic compositions with (Pb-206/Pb-204)(i)of 18.646-19.010, (Pb-207/Pb-204)(i)of 15.767-15.786 and (Pb-208/Pb-204)(i)of 39.113-39.159, respectively, and homogeneous Hf isotopic values yielding epsilon Hf (152 Ma) values from -6.9 to -9.5 with T(DM2)ages of 1680 to 2214 Ma, collectively suggesting that the granitic magma was probably derived from the remelting of ancient infracrustal materials in the basement of the Nanling region. Consequently, we consider that the Junye granites are the products of partial melting of Paleoproterozoic infracrustal medium- to high-K metamorphic basaltic rocks in the Cathaysia Block, which was caused by the underplating of coeval mantle basaltic magmas that provided abundant heat energy for melting in a tectonic setting, with lithospheric extension and thinning during the late Jurassic period.