The relationship between plate tectonics and the reworking of continental crust remains controversial. Multistage, homblende-free, S-type granites across the Malay Peninsula Sn belt are ideal for investigating this research question. Here we present zircon U-Pb ages, in-situ apatite Nd and zircon Hf isotope data, and whole-rock major and trace element data for these S-type granites and spatially associated dykes. Four generations of Permian-Triassic (276-272, 262-260, 231-222, and 202 Ma) S-type granites were identified. The different S-type granites show distinct in-situ zircon Hf and apatite Nd isotopic compositions, implying generation from different sedimentary protoliths. Input of mantle-derived components for the formation of all these S-type granites, further indicating that both continental crustal reworking and growth occurred in the Malay Peninsula during the Permian-Triassic. A 250 Ma dolerite dyke in the Eastern Province was derived from an E-MORB-like mantle source. However, a 202 Ma monzonite dyke in the Western Province, was derived from mafic magmas produced by the melting of enriched mantle, followed by subsequent incorporation of crustal materials. All these S-type granitic magmas were reduced that inherited from sedimentary protoliths, which were favourable for Sn mineralization. Apatite F-Cl concentrations and F/Cl ratios in the S-type granites and related dykes changed systematically through time. We infer that the formation of these S-type granites and related dykes corresponds to the Palaeo-Tethyan evolution (i.e., early subduction of Palaeo-Tethyan oceanic lithosphere and subsequent collision between the Sibumasu and Indochina blocks). Our study also support that multistage S-type granites can be generated in distinct tectonic environments at different times in the same region. (C) 2020 International Association for Gondwana Research. Published by Elsevier B.V. All rights reserved.