Since the beginning of the 21st century, our knowledge of the sources and fate of Hg over the Tibetan Plateau (TP), the "Roof of the World," has been greatly enhanced with growing literature. Here, we reviewed the available literature to obtain a comprehensive understanding of Hg biogeochemistry over the TP. The biogeochemical Hg cycling is characterized by the following features: (1) There are existing but limited local emission sources of anthropogenic Hg in the TP. The Indian Summer Monsoon is an important transporter of atmospheric Hg pollution into the inland TP; (2) "Cold trapping effect" plays an important role in the atmospheric Hg deposition over the TP. Glacier, vegetation, and soil act as important "sinks" of atmospheric Hg pollution; (3) Enhanced anthropogenic activities around the TP, climate warming and glacier melting have the potential impacts to affect the behavior and distribution of Hg; (4) Significant bioaccumulation of MeHg (>100 ng/g) has been found in the Tibetan aquatic food chains. Considering that transboundary transport is responsible for the widespread Hg pollution in the TP, international/regional collaborations regarding Hg emission regulations are needed to reduce the migration of Hg and to mitigate adverse Hg pollution impacts on the TP.