South China is one of the most important uranium producers in China. In terms of their host rocks, the uranium deposits in this region can be mainly divided into three types, i. e. the granite-hosted, the volcanic-hosted and the carbonaceous-siliceouspelitic rock-hosted deposits. Combined with previous investigations, this contribution summarizes several progresses in the study of uranium deposits in South China. The achievements include: (1) More precious data set of ore-forming ages were provided through pitchblende in-situ U-Pb dating; (2) Detailed mineralogical study identified the rare natural native uranium and vorlanite [(CaU6+)O-4] in the granite-related deposits; (3) It was demonstrated that the three types of uranium deposits was an interrelated entirety which was triggered by lithospheric extension during the Cretaceous-Tertiary; (4) Breakthroughs were achieved in exploring deep deposits. This special issue contains 15 papers to show some latest progresses in the study of uranium deposits in South China, mainly including those in the geological and geochemical characteristics, ages of mineralization, ore-forming processes, geodynamic settings and prospecting potential for the uranium deposits.