The Nanling Range, South China, was world-famous for hosting abundant granitoid-related copper-lead-zinc (Cu-Pb-Zn) polymetallic ore deposits and quartz vein-type wolframite (W) ore deposits, both of which have roughly similar formation ages predominately between 150 and 160 Ma with a peak of ca. 156 Ma. In this study, accessory minerals from typical Cu-Pb-Zn-bearing and W-bearing granitic rocks are compared in terms of elemental and isotopic compositions. Apatite from W-bearing granites in the Xihuashan pluton has lower epsilon(Nd)(t) value (-11.9 to -8.6) than that from Cu-Pb-Zn-bearing granitic rocks in Shuikoushan with epsilon(Nd)(t) value of -8.7 to -4.2 and initial Sr-87/Sr-86 ratio of 0.7097-0.7109. Zircon grains in Xihuashan, yielded epsilon(Hf)(t) value from -14.9 to -11.4, 8180 value from 8.6 parts per thousand to 10.4 parts per thousand, and highly variable and negative delta Li-7 value (-45.8 parts per thousand to -3.8 parts per thousand), whereas those in Shuikoushan have relatively higher epsilon(Hf)(t) value (-10.6 to -8.1), lower delta O-18 value (8.4 parts per thousand-9.7 parts per thousand), and highly variable delta Li-7 values from -12.7 parts per thousand to + 17.6 parts per thousand. In situ Hf-O-Li isotopic compositions of zircon and Sr-Nd isotopes of apatite, suggesting that the Shuikoushan granitic pluton was likely generated from dehydration melting of amphibolite from a metal-fertile mafic source in the middle-to-lower crust, whereas the Xihuashan granitic pluton could be derived from partial melting of metapelite with minor amphibolite in the middle to upper crust. The geochemical records in accessory minerals fingerprint that the Shuikoushan granitic magma was characterized by high Cl content (0.11-1.44 wt%) and logfo(2) value (> Delta FMQ +1), whereas the Xihuashan granitic magma have elevated F (3.51-4.80 wt%) and Li (3.49-42.4 ppm) contents with low logfo2 value (< FMQ + 0), which suggested moderately oxidized magmas with high Cl contents are in favor of the formation of magmatic-hydrothermal Cu-Pb-Zn deposits, whereas weakly reduced magmas with high F and Li contents could be involved in the formation of the quartz vein-type wolframite deposits. In conclusion, different source rocks and magmatic evolution processes are the key to the understanding of the Jurassic diverse granitoid-related mineralization in the Nanling Range.