The Sin Quyen deposit in northwestern Vietnam contains economic concentrations of Cu, Au and LREE, and sub-economic concentration of U. In this deposit, massive and banded replacement ores are hosted in Neoproterozoic metapelite. The paragenetic sequence includes sodic alteration (stage I), calcic-potassic alteration and associated Fe-REE-(U) mineralization (stage II), Cu-Au mineralization (stage III), and sulfide-(quartz-carbonate) veins (stage IV). The Sin Quyen deposit experienced an extensive post-ore metamorphic overprint, which makes it difficult to precisely determine the mineralization age. In this study, zircon and monazite U-Pb geochronometers and the Rb-Sr isochron method are used to constrain the timing of mineralization. Zircon grains in the ore are closely intergrown or texturally associated with hydrothermal minerals of stage II (e.g., garnet, allanite, and hedenbergite). They may contain primary fluid inclusions and display irregular zoning in cathodoluminescence (CL) images. Zircon grains are rich in U (688 to 2902 ppm) and poor in Th (0.2 to 2.9 ppm). Their delta O-18(V-SMOW) values range from 11.9 to 14.0aEuro degrees, higher than those of typical magmatic zircon. These textural and compositional features imply that zircon precipitated from O-18- and U-rich hydrothermal fluids, coeval with the minerals of stage II. Monazite occurs in close association with stage II magnetite and allanite and has low contents of Th (< 2700 ppm), indicative of a hydrothermal origin. Hydrothermal zircon and monazite have indistinguishable U-Pb ages of 841 +/- 12 and 836 +/- 18 Ma, respectively, representing the timing of Fe-REE mineralization. There is no direct isotopic constraint on the timing of the Cu-Au mineralization, but geological observations suggest that the Cu-Au and Fe-REE ores most likely formed within a single evolved hydrothermal process. In the plot of Rb-87/Sr-86 vs. Sr-87/Sr-86, the composition of bulk-ore and biotite separates from ore lie along a reference line for 30 Ma, which is consistent with the timing of metamorphism in the region. The mineralization age of the Sin Quyen deposit falls within the overall age range (740 to 860 Ma) of the regional Neoproterozoic igneous rocks. This temporal linkage, in combination with the magmatic-like sulfur isotopes of sulfide minerals (delta S-34(V-CDT) = -0.8 to 3.1), indicates that the mineralization may have a close genetic association with the Neoproterozoic igneous activity.