The Tianbaoshan, a typical Zn-Pb deposit in the Sichuan-Yunnan-Guizhou (SYG) Pb-Zn metallogenic province, is hosted by dolostone of Upper Sinian Dengying Formation. Recently, a Cu-dominant mineralization was discovered in the deep of the Tianbaoshan deposit and even formed Cu ore body. However, the origin of the Cu ores and the genetic relationship between Cu- and Zn-dominant mineralization are still unclear. This paper presents the mineralogical and isotope geochemical data of the Cu ores, integrates with those of Zn-Pb ores, in order to revealing the sources of ore-forming mineralized elements, and discussing its ore genesis and the genetic relationship with Zn-Pb ores. The microscopic observation and scanning electron microscope (SEM) analysis indicate that Cu ores are mainly composed of chalcopyrite and freibergite, followed by galena and arsenopyrite, with a small number of sphalerite and pyrite. Sphalerite is the main sulfide mineral in Pb-Zn ores, followed by galena and pyrite, with a little of chalcopyrite and pyrargyrite. In the Cu ores, sphalerite occurs as subhedral-xenomorphic granular and coexists with chalcopyrite or enclosed by chalcopyrite grain, while galena fills into the fracture of chalcopyrite, freibergite and arsenopyrite as veinlet or occurs as xenomorphic granular that was enclosed by those minerals. In the Pb-Zn ores, chalcopyrite presents as disseminated structure and distributes in sphalerite. The mineralogy, textures and structures of metal minerals in Cu- and Zn-dominant ores suggest that chalcopyrite has closely symbiotic, inserted and enclosed relationship with sphalerite and galena, and they should be formed at the same time. delta S-34(CDT) values of chalcopyrite from Cu -dominant ores range from 3. 9 parts per thousand to 4. 2 parts per thousand (mean 4. 1 parts per thousand, n = 3), similar to those of sphalerite from Zn-dominant ores (3. 3 parts per thousand to 3. 9 parts per thousand, mean 3. 5 parts per thousand, n = 3), indicating that the sources of reduced sulfur for the two types of ores are similar and all are mainly related to the sulfate in evaporites within ore-hosting strata. Pb-206/Pb-204, (207)pb/Pb-204 and Pb-208/Pb-204 values of chalcopyrite from Cu-dominant ores range from 18.441 to 18.476 (mean 18.461, n = 3), 15.731 to 15.751 (mean 15.741, n = 3), and 38.809 to 38.873 (mean 38.849, n = 3) with mu values range from 9.72 to 9.76, similar to those of galena from Zn-dominant ores (Pb-206/ Pb-204 = 18.442 similar to 18.480 (mean 18.455, n = 3), Pb-207/Pb-204 = 15.746 -15.763 (mean 15.752, n = 3), Pb-208/Pb-204 = 38.793 - 38.892 (mean 38.840, n = 3), and mu = 9.75 -9.78). This reveals a clearly crustal source of Pb, and Cu-dominant ores have the same metal sources to the Zn-dominant ores, which are all related to upper crust (the ore-hosting sedimentary rocks). Studies on mineralogy, textures and structures, S and Pb isotope geochemistry demonstrate that the sources of newly found Cu ores and Pb-Zn ores are the same, and the two types of ores were belonged to one hydrothermal system and they were the produces formed at the same age with different ore-forming stages. The ore genesis of the Tianbaoshan Cu-Pb-Zn deposit is absolutely different from MVT deposit, suggesting a special mineralization (environment) related to local geological setting. This paper has vital guiding significance for Cu ore prospecting in the deep of the Pb-Zn deposits in the SYG province, western Yangtze Block, SW China.