The Jinshachang Pb-Zn deposit, an exceptionally radiogenic Pb-enriched sulfide deposit, hosted by dolostone of the Upper Sinian (Neoproterozoic) Dengying Formation and the Lower Cambrian Meishucun Formation, is located in the western Yangtze Block, about 300 km northeast of Kunming city in southwest China. Ore bodies in this deposit are dominated by strata-bound type and steeply dipping vein type. Primary ores in these two types are composed of sphalerite, galena, fluorite, barite and quartz with massive, banded, veined and disseminated structures. Twenty-seven ore bodies in the Jinshachang deposit host 4.6 million tons of sulfide ores at average grades of 4.07 wt.% Pb and 5.03 wt.% Zn. Quartz separates from the sulfide ores have delta D-H2O values ranging from -137 parts per thousand to -86.2 parts per thousand with an average of -114 parts per thousand (n = 7), lower than those of magmatic, metamorphic and meteoric water, suggesting a contribution of organic water. delta S-34(CDT) values of ninety-one sulfide separates range from +1.1 parts per thousand to +13.4 parts per thousand with an average of +5.7 parts per thousand, lower than those of evaporites (delta S-34(CDT) = +15 parts per thousand to +35 parts per thousand) in the Cambrian to Triassic sedimentary strata in NE Yunnan province. delta S-34(CDT) values of eight barite separates range from +32 parts per thousand to +35 parts per thousand (average +34 parts per thousand), within the range of evaporites. These data suggest that S2- in the hydrothermal fluids derived from evaporites by thermo-chemical sulfate reduction (TSR), whereas SO42- directly originated from the evaporites. Six sulfide separates have highly radiogenic Pb-206/Pb-204 ratios ranging from 20.74 to 21.18 (average 20.92), Pb-207/Pb-204 ratios ranging from 15.85 to 15.89 (average 15.87), and Pb-208/Pb-284 ratios ranging from 40.89 to 41.42 (average 41.16). The Pb isotopes of the sulfides plot above the upper crust Pb average evolution curve and overlap the Cambrian sedimentary rocks, but are different from the Sinian dolostone. This indicates a crustal source of Pb most likely derived from the Cambrian sedimentary rocks. The initial Sr-87/Sr-86 ratio of seven main stage sphalerite separates from the Jinshachang deposit is 0.713, which is higher than those of the Upper Sinian Dengying Formation dolostone (0.708-0.710), Lower Cambrian carbonates (0.708-0.710), Devonian to Lower Permian sedimentary rocks (0.707-0.711) and Middle Permian Emeishan flood basalts (0.704-0.708), and lower than those of the Proterozoic folded basement rocks (0.724-0.729), but similar to those of Lower Cambrian black shale (0.712-0.714). Therefore, the Sr isotope data of the sphalerite support the view that the Lower Cambrian sedimentary rocks, in particular the black shale, were important source of metals. The main stage sphalerite separates have an Rb-Sr isotopic age of 206.8 +/- 3.7 Ma, reflecting the timing of Pb-Zn mineralization. This study suggests that the Jinshachang Pb-Zn deposit is an epigenetic, thrust fold-controlled and strata-bound deposit with fluids and metals derived from the Cambrian sedimentary strata. (C) 2014 Elsevier Ltd. All rights reserved.