The Tengchong-Lianghe tin district in northwestern Yunnan, China, is an important tin mineralization area in the Sanjiang Tethyan Metallogenic Domain. There are three N-S trending granite belts in the Tengchong-Lianghe area, with emplacement ages ranging from Early Cretaceous to Late Cretaceous and Early Cenozoic. Tin mineralization is spatially associated with these granitic rocks. However, the petrogenetic link between the tin deposits and the host granites is not clear because of the lack of age data for the tin mineralization. We investigate the possibility of direct dating of cassiterite from three typical tin deposits in the Tengchong-Lianghe tin district, using laser ablation multicollector inductively coupled plasma mass spectrometry (LA-MC-ICP-MS). In situ LA-MC-ICP-MS dating of seven cassiterite samples from the Lailishan (LLS-1 and LLS-2), Xiaolonghe (XLH, WDS, DSP, and HJS), and Tieyaoshan (TYS) tin deposits yielded well-defined Pb-206/Pb-207-U-238/Pb-207 isochron ages. To assess the accuracy of the in situ U/Pb dating of cassiterite, Ar-40/Ar-39 dating of coexisting muscovite (in samples LLS-1, DSP, and TYS) was also performed. The cassiterite in situ U/Pb ages (47.4 +/- 2.0, 71.9 +/- 2.3, and 119.3 +/- 1.7 Ma, respectively) are in excellent agreement with the coexisting muscovite Ar-40/Ar-39 ages (48.4 +/- 0.3, 71.9 +/- 1.4, and 122.4 +/- 0.7 Ma, respectively). The U/Pb ages of cassiterite combined with the Ar-40/Ar-39 ages of muscovite indicate that there are three tin mineralization events in this district: the Lailishan tin deposit at 47.4 +/- 2.0 to 52 +/- 2.7 Ma, the Xiaolonghe tin deposit at 71.6 +/- 2.4 to 3.9 +/- 2.0 Ma, and the Tieyaoshan tin deposit at 119.3 +/- 1.7 to 122.5 +/- 0.7 Ma. These ages are highly consistent with the zircon U/Pb ages of the host granites. It is su.ggested that the Cretaceous tin mineralization might have taken place in a subduction environment, while the Early Tertiary tin metallogenesis was in a postcollisional geodynamic setting.