XIE Xiang-li1,2, ZHOU Xiang3, CAO Wei-cheng3, ZANG Meng-lu3, SHI Liang-xiang3, WANG Lin-jiang2,3
(1. College of Chemical and Biological Engineering, Guilin University of Technology, Guilin 541004, China;
2. Key Laboratory of Mineralogy and Metallogeny, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510460, China;
3. College of Materials Science and Engineering, Guilin University of Technology, Guilin 541004, China )
Abstract: Taurine layered double hydroxide (TAU-LDH) and ibuprofen layered double hydroxide (IBU-LDH) were prepared with calcinated-hydration method, by using taurine (TAU) and ibuprofen (IBU) as interlayer anions. XRD and FT-IR were used to characterize the structure of intercalation compounds. Drug release characteristics of TAU-LDH and IBU-LDH were investigated with a dissolution test in a phosphate buffer dissolution (PBS). The UV-Vis test results show that the drug release in the interlayer of LDHs is a slow process. TAU-LDH compound releases 85% of TAU in 40 min and 100% of TAU in 180 min, while IBU-LDH compound releases 88% of IBU in 40 min and 100% of IBU in 180 min. This data suggested that these drug-inorganic hybrid materials can be used as an effective drug delivery system.
Key words: layered double hydroxide; taurine; ibuprofen; intercalation; drug controlling release
E-mail: wlj@glite.edu.cn
ACTA MINERALOGICA SINICA Vol. 32, No. 4, 2012, Page 481-485
