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Elevated yield of Monacolin K in Monascus purpureus by fungal elicitor and mutagenesis of UV and LiCl TEXT SIZE: A A A

In China, Monascus spp., a traditional fungus used in fermentation, is used as a natural food additive. Monascus spp. can produce a secondary metabolite, monacolin K namely, which is proven to be a cholesterol-lowering and hypotensive agent. Hence, recently, many researchers have begun focusing on how to increase the production of monacolin K by Monascus purpureus. In the present study, we investigated the effect of the fungal elicitor and the mutagenesis of UV & LiCl on the amount of monacolin K produced by Monascus purpureus. The fugal elicitor, Sporobolomyces huaxiensis, was isolated from tea leaves and its filtrate was added into the culture filtrate of Monascus purpureus during growth to induct the production of monacolin K. The results showed that the highest amount of monacolin K produced by the liquid fermentation was 446.92 mg/mL, which was produced after the fungal elicitor was added to the culture filtrate of Monascus purpureus on the day 4; this amount was approximately 6 times greater than that of the control culture filtrate, whereas the highest amount of monacolin K produced by the mutated strain was 3 times greater than the control culture after the irradiation of UV light in the presence of 1.0 parts per thousand LiCl in the medium.

  Publication name  BIOLOGICAL RESEARCH Volume: 44  Issue: 4  Pages: 377-382  Published: 2011
  Author(s)

 Sun, Jia-Long; Zou, Xiao; Liu, Ai-Ying; Xiao, Tang-Fu

  Corresponding author  

 Liu Aiying
 danielsjl@163.com, ayliu6@yahoo.com
 Guizhou Univ, Inst Fungus Resources, Guiyang 550025, Peoples R China

  Author(s) from IGCAS  SUN Jialong, XIAO Tangfu

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